Cotula cinerea Del. belongs to the family Asteraceae. It is widely used in the traditional medicinal system for the treatment of various ailments such as colic. Cotula cinerea Delile [family COMPOSITAE ] (stored under name); Verified by Not on Brocchia kotschyi; Cotula kotschyi; Cotula cinerea; Brocchia cinerea. Abstract: The phytochemical investigation of Cotula cinerea Del. afforded eighteen Keywords: Cotula cinerea Del.; Asteraceae; Flavonoids; Germacranolide.

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Abstract The objective of this work was to investigate the cytotoxicological effect of the cinerex hexane, ethyl acetate, and n -butanol of Cotula cinerea and Salvia verbenaca in addition to the clnerea oil of Cotula cinerea. However, and despite the widespread use of these plants in Moroccan traditional folk medicine, to the best of our knowledge, no information has been previously reported on the anticancer activity of Moroccan Cotula cinerea and Salvia verbenaca.

The collected aerial parts were left under shade at room temperature until complete drying. This was observed for both cell lines.

TrekNature | Cotula cinerea Photo

Composition chimique et isolement des deux principaux constituants. This work was therefore initiated cinrea order to evaluate the in vitro antiproliferative effect of Cotula cinerea and Salvia verbenaca extracts and essential oil against cothla RD and Vero cell lines. Ccotula the case of the RD cell line, the Cotula cinerea hexane extract showed the higher cytotoxic effect followed by the ethyl acetate, the essential oil, and the n -butanol extract.


The hexane, ethyl acetate, and n -butanol extraction yields were, respectively, 1. The cinrrea tumor tested cell lines used in this study were RD Human Embryonal Rhabdomyosarcoma cancerous cell lines: Phillips Cotula pterocarpa DC. The Royal Society of New Zealand. In this work we were interested in exploring the potential cytotoxicological effect of Cotula cinerea and Salvia verbenaca from Morocco.

In the same conditions, higher concentrations were needed in the case of Salvia verbenaca extracts. After 30 minutes of incubation at room temperature, absorbance was measured at nm using an ELISA plate reader. The test is based on the biotransformation of MTT into formazan crystals by mitochondrial dehydrogenases of living cells. Sports Turf Research Institute. The evaluation of cell viability has cotua achieved through the use of MTT 3- 4,5-dimethylthiazol-2,5-diphenyl tetrazolium bromide assay.

Cotula australis Sieber ex Cineea. The essential oil of Cotula cinerea aerial parts was extracted by hydrodistillation using a Clevenger-type apparatus.

Examination of the cytotoxic activity of the Cotula cinerea individual compounds would give crucial information regarding the exact mechanism of this plant in antitumor activity. By using this site, you agree to the Terms of Use and Privacy Policy. Growing Wildly in the Middle East: Cotula is cotulw largest genus found in the Southern Hemisphere of the tribe Anthemideae.


An examination of the obtained results showed that the cytotoxic effects of the investigated plants extracts were different according to the tested cell line with an efficient activity of Cotula cinerea compared to Salvia verbenaca.

Comparative evaluation of antioxidant and insecticidal properties of essential oils from five Moroccan aromatic herbs. Cjnerea socialis Hilliard Cotula sororia DC. Further studies are obviously needed to elucidate the exact mechanism of Cotula cinerea in cytotoxic activity.

In the case of the Vero tumor cell line, Table 1 reveals that Cotula cinerea essential oil showed the highest cytotoxic capacity with the lowest IC 50 value Then, solvents of the different obtained extracts were evaporated and the dried residues were used to explore their cytotoxic effect.

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From Wikipedia, the free encyclopedia. After 24 h incubation, cells were then treated with the essential oil of Cotula cinerea or its extracts cotkla, ethyl acetate, and n -butanol in addition to those of Salvia verbenaca.

Burtt Cotula reptans Benth. To date various bioactive compounds have been tried against cancer. Cotula cotuloides Steetz Druce Cotula cryptocephala Sch. El Btaouri et al. Prolonged cancer treatment is generally costly to patients and complicates patient follow-up in hospital.