Hepatocarcinoma fibrolamelar un tumor de adultos jóvenes poco frecuente. . Dentro de los diagnósticos diferenciales se debe considerar la HNF, CHC. Protocolo de diagnóstico diferencial de las lesiones ocupantes de espacio en el hígado cirrótico Clinical management of hepatocellular carcinoma. Su diagnóstico suele ser tardío, ya que se presenta en pacientes jóvenes, sin . a las del hepatocarcinoma en la que es necesario un diagnóstico diferencial.

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Case reports in oncology ; 5 1: Contrast enhancement of liver lesions in cirrhotic patients: Sonographic morphometry of the liver and biliary tract in porcine models submitted to experimental biliary obstruction. Hepatobiliary-specific MR contrast agents: Such contrast agents are absorbed by hepatocytes via OATP1 transporter polypeptide adenosintriphosphate-dependent organic anion transporterthe same as the bilirubin transporter.

Two liver nodules are seen in the segment VIII arrows as well as a larger nodule, in the segment VI arrowheadsall of them contrast-enhanced in the arterial-phase, washout in the delayed-phase, and without uptake in the hepatobiliary-phase, characterizing HCCs. The presence of intralesional fat is not usually found in FNH and suggests the diagnosis of adenoma — adenomatosis, in the present case —, with a very different prognosis and approach. The avascular lesion arrowhead is secondary to post-treatment alteration.

Additionally, hepatobiliary contrast agents contribute to the diagnosis of small, benign focal lesions frequently found in patients with neoplasias, particularly FNH Figure 8. The biliary excretion of hepatobiliary contrast agents allows for the anatomical and functional characterization of intra- and extrahepatic biliary tract. The characterization of focal liver lesions is very important.

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All the contents of this journal, except where otherwise noted, fiferencial licensed under a Creative Commons Attribution License. As the gadoxetic acid dose corresponds to one quarter of the habitual extracellular gadolinium dose, the arterial phase acquisition time is critical, requiring temporal precision methods, such as real time visualization of the contrast progression through the arterial system, for the success in this phase acquisition.

No hepatobiliary contrast uptake is observed.

So, hepatobiliary contrast agents combine the pharmacodynamic features of extracellular gadolinium usual dynamic difwrencial with the delayed hepatobiliary phase, adding functional information to the MRI hepatocarcijoma and enhancing its diagnostic accuracy 124 – 6. New proposal for the staging of nonalcoholic steatohepatitis: The diagnostic performance of MRI in the detection of HCCs of all sizes increases with the utilization of hepatobiliary contrast agents 1 Magnetic resonance imaging is considered the best imaging method for evaluating such lesions, but does not allow for the diagnosis in all cases.


Further potential hepatobiliary contrast applications include the evaluation of the functional hepatic reserve before partial hepatectomy; ddiferencial of live donor’s hepatic function as well as evaluation of early liver failure after transplant 4. Female, year-old patient presenting with colon cancer. Open in a separate window.

However, in cases of advanced cirrhosis, the contrast uptake by the liver parenchyma may be compromised by decreased hepatocytes function, which would result in reduction of the method’s accuracy to detect HCCs 4 The imaging evaluation of the biliary system has been approached by a series of publications in the Diagnsotico radiological literature 24 – Such a lesion shows intense and homogeneous contrast uptake in the arterial-phase, with decay in the portal and delayed phases, presenting greater hepatobiliary contrast uptake than the adjacent parenchyma, suggesting FNH as the first diagnostic hypothesis.

Radiology ; 1: In cirrhosis, the hepatobiliary contrast uptake by the nodules depends on their differentiation stage and on the presence of functioning hepatocytes. Find articles by Daniella Braz Parente. Adenomas are well defined, homogeneous or heterogeneous lesions.

HEPATOCARCINOMA DE CÈLULAS CLARAS by marta garnica ureña on Prezi

Hemangiomas generally present typical imaging findings and are easily diagnosed by computed tomography or MRI with extracellular gadolinium contrast agent. Eur J Cancer ; 49 However, the presence of intralesional fat was detected on out-of-phase T1-weighted sequence. Calcification in focal nodular hyperplasia: Adenomas are composed of hepatocytes containing glycogen and lipids surrounded by a capsule.

Thus, the lesions enhancement in the hepatobiliary phase depends upon the expression and activity of such transporters, determining characteristic enhancement patterns depending on the presence or absence of functioning hepatocytes. However, MRI does not allow for the diagnosis in all cases whose etiology remains undetermined.

Metastases do not contain functioning hepatocytes or biliary ducts, and do not show contrast uptake during the hepatobiliary phase. Diagnostic challenges and pitfalls in MR imaging with hepatocyte-specific contrast agents.

Focal liver lesions enhancement may be less intense during the dynamic study, particularly in the arterial phase, because the recommended dose of gadoxetic acid is lower than the habitual extracellular gadolinium dose 5. Adverse effects of hepatobiliary contrast agents rarely occur and, if present, are similar to the ones reported in the use of extra-cellular gadolinium. Female, year-old, asymptomatic patient presenting with a hypervascular liver nodule to be clarified, without intralesional fat and without central scar.


This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Fibrolamellar variant of hepatocellular carcinoma.

Rarely, there is hepatobiliary contrast uptake by adenomas and, in cases where it occurs, such hepatocarxinoma uptake tends to be preferentially peripheral in the hepatobiliary phase 124. However, in some cases, especially those of small lesions without central scarone cannot differentiate between FNH and adenoma due to overlapping imaging findings 1 ciagnostico, 4. Imaging of fibrolamellar hepatocellular carcinoma. Diffusion- and T2-weighted sequences may be acquired after hepatobiliary contrast agent injection, considering that there is no significant interference effect.

Reporte de un caso. As gadoxetic acid is utilized, the hepatobiliary phase occurs in 20 minutes, so it is recommended that the diferdncial of sequences acquisition be changed in order to optimize the acquisition time. Two hypervascular lesions arrows are seen with intermediate signal intensity on T1- and T2- weighted sequences, showing contrast uptake in the hepatobiliary-phase.

European journal of surgical oncology: The utilization of such contrast agents increases the index of detection of hypo- and hypervascular metastases Figure 7.

The use of hepatobiliary contrast agents increases the diagnostic accuracy of magnetic resonance imaging and reduces the number of non-specific liver lesions.

High-degree dysplastic nodules lose the portal vascularization and start gaining abnormal arterial vascularization. GCR ; 6 1: The utilization of hepatobiliary contrast agents may reduce the necessity of invasive diagnostic procedures as well as of further investigation with other imaging methods, and imaging follow-up, reducing costs and the anxiety of both patients and hepatocarcinoms team.