Chlorothiazide should be used cautiously in patients with renal disease resulting in severe renal impairment because the drug decreases the glomerular. Easy to read FDA package insert, drug facts, dosage and administration, and adverse effects for Diuril (Chlorothiazide). Chlorothiazide sodium for injection, USP is a diuretic and a vial containing: Chlorothiazide sodium equiva- . toxicity. Refer to the package insert for lithium.
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Although the manufacturer for Questran recommends that other medicines be taken at least 1 hour before or hours after cholestyramine, it has been recommended that thiazides be administered at least 4 hours before or after cholestyramine to minimize the reduction in absorption.
Treatment with clozapine has been associated with QT prolongation, torsade de pointes TdPcardiac arrest, and sudden death. Moderate Additive hypokalemia may occur when non-potassium sparing diuretics, including thiazide diuretics, are coadministered with other drugs dkuril a significant risk of hypokalemia, such as corticosteroids.
Concurrent pafkage of clozapine and medications known to cause electrolyte imbalance may increase the risk of QT prolongation. Infants and Children 6 months to 1 year. Minor Aripiprazole may enhance the hypotensive effects of antihypertensive agents. Extravasation must be strictly avoided during IV administration of chlorothiazide to prevent tissue necrosis. Moderate Olanzapine may induce orthostatic hypotension and thus enhance the effects of antihypertensive duiril.
Therefore, when chlorothiazide sodium and non-steroidal anti-inflammatory agents are used concomitantly, the patient should be observed closely to determine if the desired effect of the diuretic is obtained. Major Dose adjustment of vitamin D analogs may be necessary during coadministration with thiazide diuretics.
The reconstituted solution pac,age clear and essentially free from visible particles. Moderate Coadministration of thiazide diuretics and antineoplastic agents such as cyclophosphamide may result in reduced renal excretion of the antineoplastic agent and therefore increased myelosuppressive effects. Absorption of chlorothiazide is approximately doubled when taken with food.
The precise mechanism for such events is unclear but likely immune-mediated and may be related to an effect of oxypurinol; elevated oxypurinol concentrations appear to be associated with hypersensitivity reactions; decreased clearance of this metabolite may occur with renal impairment and with the concurrent use of thiazide diuretics. Discard unused portion – Store at controlled room temperature between 68 and 77 degrees F.
Patients should be informed about measures to prevent orthostatic hypotension, such as sitting on the edge of the bed for several minutes prior to standing in the morning, or rising slowly from a seated position. Chlorothiazide provides additive hyperglycemic effects and helps minimize fluid retention associated with diazoxide.
Clinically significant hyponatremia has been reported during therapy with vortioxetine. According to the manufacturer, chlorothiazide is specifically contraindicated in patients with sulfonamide hypersensitivity. Thiazide diuretics are contraindicated in patients with known thiazide diuretic hypersensitivity.
Discard unused portion of the reconstituted solution. Blood pressure and heart rates should be monitored closely to confirm that the desired antihypertensive effect is achieved. Moderate Concomitant use of medicines with potential to alter renal perfusion or function such as diuretics, may increase the risk of acute phosphate nephropathy in patients taking sodium phosphate monobasic monohydrate; sodium phosphate dibasic anhydrous.
Thiazide diuretics increase the excretion of water by inhibiting the reabsorption of sodium and chloride ions at the distal renal tubule.
It appears that the effects of thiazide diuretics on glycemic control are dose-related and low doses can be instituted without deleterious effects on glycemic control. Concurrent use with baclofen and antihypertensive agents may result in additive hypotension. Discontinuation of sertraline should be considered in patients who develop symptomatic hyponatremia.
Hypercalcemia may be exacerbated by coadministration of vitamin D analogs and thiazide diuretics. Severe Hypokalemia or hypomagnesemia may occur with administration of potassium-depleting drugs such as loop diuretics and thiazide diuretics, increasing the potential for dofetilide-induced torsade de pointes. Methenamine; Sodium Acid Phosphate: Thiazide diuretics may increase urinary pH, acting as a urinary alkalinizer, thus reducing urinary excretion and increasing blood concentrations diurkl the amphetamine.
Vial stoppers do not contain ibsert rubber latex.
Careful blood pressure monitoring is recommended. If isoproterenol is used concomitantly with antihypertensives, the blood pressure should be monitored as the administration of isoproterenol can compromise the effectiveness of antihypertensive agents.
Coadministration may result in an additive risk of developing hyponatremia. Amphotericin B liposomal LAmB: Hawthorn use in combination with antihypertensive agents may lead to additional reductions in packave pressure in some individuals.
Dilution Chlorothiazide – GlobalRPH
Patients with pre-existing hypovolemia or hypotension should have their condition corrected before diuretics are initiated. Thiazide diuretics, such as chlorothiazide, distribute into breast milk, and it has been recommended by some manufacturers that women not nurse while receiving selected thiazide diuretics.
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to use whenever solution and container permit.
Additive reductions diudil blood pressure may be seen when fish oils are used in a patient already taking antihypertensive agents.
Akorn – Sodium Diuril® (chlorothiazide sodium)
During clinical trials of bortezomib, hypotension was reported in packagge 12 percent of patients. Patients who choose to take CoQ10 concurrently with antihypertensive medications should receive periodic blood pressure monitoring.
In patients with diabetes mellitus who are receiving chlorothiazide, blood glucose levels should be monitored frequently. Moderate Sulfinpyrazone facilitates urinary excretion of uric acid and thereby decreases plasma urate concentrations. Chlorothiazide should be used cautiously in patients with renal disease resulting in severe renal impairment because the drug decreases the glomerular filtration rate and may precipitate azotemia in these patients. Periodic evaluation of blood pressure is diugil during concurrent use of methylphenidate and antihypertensive agents, particularly during initial coadministration and after dosage increases of methylphenidate.