Capitulo 1 – Download as PDF File .pdf), Text File .txt) or read online. Introducao-Bioestatística – Uploaded by. by Deborah Rumsey and if you can read in portuguese: Introdução a Bioestatística para simples mortais, by Ulysses Doria Filho) and take my. . -assassinos-e-poetas-que-sonharam-a-independencia-do-brasil-pedro-doria .

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Here we have a problem, Immortal Time Bias.

Combination therapy for non-believers, and believers too! Keep this in mind! Take another look at the antibiotics doses table. Therefore, if you read an article showing a possible association between bioestatisticca therapy and lower mortality and take this as true I can recommend you two books Statistics for Dummies, by Deborah Rumsey and if you can read in portuguese: Meaning, if you wanna treat them, do it with the right dose!

The only group which received polymyxin at uljsses dose was the VCT group. The primary outcome was infection related mortality, which was determined by the attending physician another bias here. So, if I begin with polimyxin and just after 3 days add amikacin, this guy who recive amikacin is the same that our 5th day drunk guy. Because he had to survive our attempts to kill him as intensivists until day 5.

The antibiotic dose was included in the multivariate model.

And also other strange things happened. This is gonna be a revolving theme here, so keep your eyes open! Therefore, beer drinkers have lower mortality than sober patients.


But after a multivariate analysis the authors throw the results saying the risk of infection related mortality is 8x greater in MT group fklho 6x greater in NVCT group when compared to VCT group. I agree that is not easy to study the same bacteria, for example, Klebsiella pneumoniae carbapenemase Gen2.

Combination therapy for non-believers, and believers too! – ICU Revisited

For me the idea of using lower doses to avoid adverse affects might increase bacterial resistance. In their majority, the most cited, are observational trials. Patients in the validated polymyxin combination therapy had more severe infections and more serious disease, monotherapy group was older.

Another thing is to realize that the study compares different sites of infection and different bacterias. Patients were included if: Recently I did a review of bioeetatistica about bioestatistlca therapy for multi-drug resistant bacterias and soon you will see here. Is the HCAP concept a lie?

Escritos de Fernando Macedo e Thais Barros: Palavras 2

S Army — Delta associates — Memegenerator. There it is, nebulized and intravenous are the same? Why I hate tramadol but sometimes use it.

I can show you that a patient who drinks beer at 5th day of ICU have lower mortality than a patient who does not. Data and results Patients in the validated polymyxin combination therapy had more severe infections and more serious disease, monotherapy group xoria older.

This was a unicentric, retrospective study that from evaluated antibiotic combinations to guide therapy in patients with extensively drug-resistant gram negative bacilli XDR GNB infections of any site. Go hit the books then.


Combination therapy for non-believers, and believers too!

Nothing but the whole truth. To begin with, I can do an observational trial, either retrospective or prospective, showing that doctors who drink wine 7 days a week have more sex. From a statistical point of view, the drinker only begin to exist at day Both groups with combined therapy had more infections caused by Klebsiella pneumoniae and Pseudomonas bioestatistcia when the monotherapy group more Acinetobacter baumannii infections.

Moving on… The eligible patients were divided in three groups: Now, to study Klebsiella pneumoniae carbapenemase Gen2 causing blood stream infection and compare between monotherapy vs combined therapy? All these information makes me wonder about the results of the multivariate analysis. The median of adequate treatment for monotherapy group was ZERO! Interestingly, was considered polymyxin use any of: Even if the patients in the Biosetatistica group were more sick, it was the only group which received adequate dose treatment.

The ART trial and how lung recruitment died. One interesting fact is that even with lot of difference among polymyxin doses no difference in nephropathy RIFLE was showed.

If you do agree, read the literature we have available today about combination therapy. Is that honest to compare this group with others?

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