As Disintegrating agent: Kyron T has a very high swelling tendency of hydration either in contact with water or G.I. fluids causing fast disintegration without. Article | The purpose of present study was to compare Kyron T with other superdisintegrants and optimize the fast dissolving tablet of. industry to mask the taste of bitter medicine to achieve stability and drugs. It is white to off white fine powder, swellable in water. KYRON T is derived from.

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The prepared tablets were evaluated for physical parameters such as hardness, thickness, diameter, friability, weight variation, in vitro dispersion time, in vitro disintegration time, wetting time and water absorption ratio. Formulation F-X was emerged -t314 the overall best formulation based on drug release characteristics in pH 6.

Handbook of Pharmaceutical Excipients.

Export Data and Price of kyron t | Zauba

Disintegrant Excipient Tablet computer Compliance behavior. Kyron T has a very high swelling tendency of hydration either in contact with water or G.

Hardness of the tablet, which is the force applied across the diameter of the tablet to break a tablet into halves, was measured using a Pfizer tablet hardness tester. Required quantity is from 2. Besides, our company is proficient enough to provide effective solutions to various industry’s specific problems and needs. Showing of f-314 extracted citations.

Kyron T-314

Owing to these features, we have been able to serve industries like Pharmaceutical, Nutracuetical ykron Cosmetic Industries. Formulation and optimization of mouth dissolve tablets containing rofecoxib solid dispersion Omaima A.

The flow prpoperties were shown in Table 3. Skip to search form Skip to main content. The co-processed superdisintegrants were prepared by solvent evaporation method. The simple physical blends and co-processed mixture of superdisintegrants were characterized for angle of repose, bulk density, tapped density, Carr’s index, Hausner’s ratio and compatibility studies by FTIR spectroscopy.


Analysis of drug release data indicated that formulation F-X followed first order kinetics. The bulk density was determined as the ratio of weight to the volume of sample.

Get best deals for coconut. Author’s work Hide Show all. Abstract Orodispersible tablets ODTsalso known as fast melt, quick melts, fast disintegrating have the unique property of disintegrating in the mouth in seconds without chewing and the need of water.

Showing of 21 references. Melt-in-mouth tablets each containing 10 mg of metoclopramide hydrochloride were prepared by direct compression method employing crospovidone, Kyron T, physical blend and co-processed mixture of both the superdisintegrants in different ratios 1: Erick Legrand T3-14 opinion on pharmacotherapy Cumulative percent drug released was calculated and kinetic study models like zero-order and first-order were applied [ 15 ].

All the ingredients except granular directly compressible excipient were passed through sieve separately. AminRuchi AgrawalRikita K. Department of Pharmaceutics, K.

In the present investigation, a novel multifunctional co-processed superdisintegrants consisting of crospovidone t3-14 Kyron T were fabricated by solvent evaporation method to develop melt-in-mouth tablets of metoclopramide hydrochloride with a view to enhance patient compliance by direct compression method. Table 1 shows the flow property of crospovidone, Kyron T, their physical blends and co-processed mixtures with USP specifications.

ChaudhariVinod A. The reasons for selection of crospovidone are high kron activity, pronounced hydration capacity and little tendency to form gels. Kjron indicates that the drug release process is first order in nature.

By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy PolicyTerms of Serviceand Dataset License. In comparison to direct compression t-31 containing the physical blends of crospovidone and Kyron T, a faster drug release was observed from the tablets made from coprocessed superdisintegrants which might be t-3144 to increased porosity.


Table 1 shows the parameters associated with flow of physical blend and co-processed mixture of crospovidone and Kyron T It is a very high purity polymer used in pharmaceutical formulations as a super fast disintegrant as kyeon as dissolution improver in solid dosage forms like tablets, capsules, pellets etc.

At intervals of 1 month, the tablets were visually examined for any physical changes and evaluated for in vitro drug release studies [ 16 ]. Kyron T is high molecular weight polymer, so doesn’t get absorbed by body tissue and is safe for human consumption.

Formulation design and optimization of mouth dissolve tablets of nimesulide using vacuum drying technique Mukesh GohelMadhabhai M. Since mechanical integrity is of paramount importance in successful formulation of melt-in-mouth tablets, the hardness of the tablets was found to be in the kyrom of 3. I agree to the terms and privacy policy.

A quantity of powder equivalent to 10 mg of metoclopramide hydrochloride was extracted in pH 6. These are manufactured using high quality basic material which is procured from reliable vendors.

Evaluation of KYRON T-314 ( Polacrillin Potassium ) as a novel super disintegrant

References Publications referenced by this paper. SammourMohammed A. Thus coprocessing of two superdisintegrants with wicking and swelling properties leads to the rapid disintegration of tablets in contact with saliva within few seconds and also serves as a multifunctional excipient [ 9 ].

It has no physiological action at recommended dosage and it is non toxic.