Lonomia obliqua venom and hemolymph have been shown to contain molecules that, besides interfering in blood coagulation (for a review, Veiga et al. ). Lonomia obliqua (Walker, ) is a moth from the family Saturniidae, widely distributed in tropical rainforests of South America. In its larval stage (caterpillar) it . Rev Assoc Med Bras (). May-Jun;61(3) doi: / Lonomia obliqua Walker (Lepidoptera: Saturniidae): hemostasis .
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Further studies encompassing the purification of active components of venom are needed to further elucidate the effects presented in the cell lines used obliqus this work. It is known that NO has an important role in the progression of gliomas Himlin et al. Probably the mechanism leading to cell death in fibroblasts by exposure to the venom is mutated in cancer cells studied in this work.
The caterpillars are themselves extremely cryptic, blending in against the bark of trees, where the larvae commonly aggregate. Cell counting After venom treatment of the UMG cell line, medium was removed, cells were washed in PBS and detached with trypsin 0.
Lonomia obliqua – Wikipedia
Similar treatments with UMG cells in proliferation and HT cells in quiescence also showed no significant differences data not shown. Intracerebral haemorrhage after contact with Lonomia caterpillars. The poison only takes effect in fairly large amounts; in order to experience the extreme effects caused by the toxins, a human victim would probably need to be stung at least 20 to times because each sting only injects a minute amount of venom.
Previous studies have shown the diversity of active principles present in L. Cell viability after treatment with L.
MTT analyses indicate that L. On the other hand, active principles that circulate in the hemolymph and therefore are present in the spicules may be inhibited by molecules produced in only a specific cell type or tissue, leading to the wrong assumption that such an activity is not present in that specific structure. The histology is poorly characterized owing to the coagulopathy-preventing biopsies in the acute phase of the illness.
At first the cause could not be determined, although each victim stated they had “just handled a bunch of leafy branches to break the trail or gather vegetation. Among animals known to produce pharmacologically active molecules that interfere in human cell physiology, the caterpillar Lonomia obliqua has become the focus of toxicological studies due to recent findings about its venom constituents. Well camouflaged, they ohliqua rows of tubercles crowned with whorls of easily detachable spines of different sizes.
Canadian Medical Association Journal.
From Wikipedia, the free encyclopedia. These mechanisms of increasing or decreasing cellular proliferation are extremely lnomia for the understanding of the venom effects in different cell types and should be a research subject for future studies.
Thomas Hospital, London, UK. In vivo effects and molecular aspects associated with the hemorrhagic syndrome”. National Center for Biotechnology InformationU. Since obliqya number of human accidents caused by these caterpillars has been increasing in the southern region of Brazil. Nevertheless, one cannot disregard that the joint action of some active principles of the venom, such as the hemolytic activity of PLA2 and the hyaluronidase activity, may have inhibitory effect on proliferation and cell viability.
Role of nitric oxide in tumour progression with special reference to a murine breast cancer model. In Argentina, these kinds of lonomi are rare and restricted to the province of Misiones. These data suggest that decreasing the concentration of nitric oxide by treating cells with the venom leads to an increase in cell proliferation in lonomoa.
After 48 h of treatment, cells were analyzed by the MTT method. Malaise, fever, nausea and myalgia followed. But, despite the decrease ,onomia NO production, the venom acts inducing proliferation of cells by other cellular mechanisms. The resulting medical syndrome is sometimes called lonomiasis.
The toxins are stored in sacks at the base of each spine.
However, when V cells were treated with the same doses and the dose of lonomiia. For Permissions, please e-mail: A diagnosis of Lonomia toxin poisoning and subsequent acute kidney injury AKI and coagulopathy was made. As these caterpillars cluster in large numbers on tree barks and blend in so well Figure 1contact with large numbers of caterpillars can occur exposing the individual to larger, more dangerous doses of venom. All experiments were performed at least three times.
By Day 2, she had melaena and was admitted to hospital. Enhancing effect lonoima a protein from Lonomia obliqua hemolymph on recombinant protein production. Results Previous studies have shown the diversity of active principles present in L.
Cell count based on the trypan blue exclusion method suggests a proliferating activity of the venom upon UMG cells. Encyclopedia of Entomology 2nd ed.
[Accidents with caterpillar Lonomia obliqua (Walker, ). An emerging problem].
Accidental poisoning with caterpillars has become increasingly frequent in southern Brazil, partly due to deforestation and elimination of natural predators [ 1 ]. The reported death rate is 2. Although few cases are recorded, a case study of a fatal encounter was published in Arquivos de Neuro-Psiquiatria: